DESIGN EXPERT 7 TRIAL DOWNLOAD HOW TO

DESIGN EXPERT 7 TRIAL DOWNLOAD HOW TO

We believe that even if the planning and analysis of a trial is undertaken by an expert statistician, it is essential that the investigators understand the implications of using an adaptive design, for example, what the practical challenges are, what can (and cannot) be inferred from the results of such a trial, and how to report and communicate the results.

Additionally, the term adaptive design has been misleadingly used as an all-encompassing label to refer to certain methods that could be deemed controversial or that have been inadequately implemented. We speculate that one factor contributing to this is that the full range of adaptations available to trial designs, as well as their goals, advantages and limitations, remains unfamiliar to many parts of the clinical community.

The pace of the uptake of adaptive designs in clinical research, however, has remained well behind that of the statistical literature introducing new methods and highlighting their potential advantages. Adaptive designs can be applied across all phases of clinical research, from early-phase dose escalation to confirmatory trials. Trials with an adaptive design are often more efficient, informative and ethical than trials with a traditional fixed design since they often make better use of resources such as time and money, and might require fewer participants. Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trialвЂ™s course in accordance with pre-specified rules.

Design expert 7 trial download